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Some degree of immunophenotype overlap among the CLL, marginal zone lymphoma, and lymphoplasmacytic lymphoma exists. If the prognosis is uncertain based upon peripheral blood circulation cytometry, lymph node biopsy needs to be pursued.
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This methylation profile is previously acquired for the MBL stage3 and stays rather secure over time. Nonetheless, some CLL have intratumor variability in specified areas, which can alter the expression of various genes and aid tumor evolution.seventy one Of Take note, this variability is bigger in U-CLL than in M-CLL which is associated with raising quantity of subclones.7,71
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